Combination effects in chemical carcinogenesis

by Dietrich SchmaМ€hl

Publisher: VCH in Weinheim, Federal Republic of Germany, New York, NY, USA

Written in English
Cover of: Combination effects in chemical carcinogenesis | Dietrich SchmaМ€hl
Published: Pages: 279 Downloads: 173
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  • Chemical carcinogenesis.

Edition Notes

Includes bibliographies and index.

StatementDietrich Schmähl ; with contributions by Martin R. Berger ... [et al.].
ContributionsBerger, Martin R.
LC ClassificationsRC268.52 .S36 1988
The Physical Object
Paginationxi, 279 p. :
Number of Pages279
ID Numbers
Open LibraryOL2124869M
ISBN 100895736705
LC Control Number88185121

Of the important health effects of ionizing radiation, three important late effects - carcinogenesis, teratogenesis and mutagenesis are of greatest concern. This is because any exposure, even at low levels, carries some risk of such deleterious effects. As the dose of radiation increases above very low levels, the risk of health effects increases. Cancer is a complex group of diseases with many possible causes. In this section you can learn more about the known causes of cancer, including genetic factors; lifestyle factors such as tobacco use, diet, and physical activity; certain types of infections; and environmental exposures to different types of chemicals and radiation.   The chemical name is 2-(2,6-dichlorophenylamino)imidazoline hydrochloride. In combination with amitriptyline, Clonidine hydrochloride administration led to the development of corneal lesions in rats within 5 days. Carcinogenesis, Mutagenesis, Impairment of Fertility. Molybdenum (Mo) Molybdenum has effects similar to manganese and vanadium, and is often used in combination with one or the other. It particularly increases the strength of the steel at higher temperatures and also improves corrosion resistance. Typical amounts of molybdenum are to percent for certain grades of A steel, and to.

The biologic effects of particles are at the core of our understanding of radon-induced lung cancer and risk models should appropriately reflect this understanding. Risk estimates for lung cancer related to radon in homes can be derived by at least two quite different approaches. In the so-called epidemiologic approach, lung-cancer data on underground miners are extrapolated from the high.   Oxidative stress is involved in the development of various cancers. In the present study, the effect of long-term administration of peroral antidiabetic metformin and pineal hormone melatonin on liver antioxidant and aerobic status in female Sprague-Dawley rats carrying mammary tumors induced by N-methyl-N-nitrosourea was substances were administered in a preventive and . This series of books, of which this volume is the first of three, will attempt to present the field of oncology divided into three major areas: etiology, biology, and therapy. This first volume deals with chemical and physical carcinogens and includes overview chapters on .   Maharishi Amrit Kalash (MAK) is an herbal formulation composed of two herbal mixtures, MAK-4 and MAK These preparations are part of a natural health care system from India, known as Maharishi Ayur-Veda. MAK-4 and MAK-5 are each composed of different herbs and are said to have maximum benefit when used in combination. This investigation evaluated the cancer inhibiting effects .

Side Effects & Safety When taken by mouth: Sassafras is POSSIBLY SAFE in foods and beverages if it is "safrole-free." In medicinal amounts, taking safrole-free sassafras is POSSIBLY Similar effects on both male and female sexual development and carcinogenesis were observed in the F2 progeny, but only if both the dam and the sire were perinatally exposed to Zer, suggesting a recessive, epigenetic mode of transmission. F3 progeny showed decreased fecundity and litter sizes, with a significant decrease in the number of males.

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Schmähl D. () Combination Effects in Chemical Carcinogenesis. In: Chambers P.L., Klinger W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology (Supplement), vol by: Book: All Authors / Contributors: Dietrich Schmähl; Martin R Berger. Find more information about: Combination effects in chemical carcinogenesis book Influence of Non-Carcinogenic Compounds on Chemical Carcinogenesis; Combination Effects in the Carcinogenesis of Cytotoxic Agents and its Possible Inhibition: Experimental and Clinical.

Combination Effects in Chemical Carcinogenesis. Von D. Verlagsgesellschaft, Weinheim/VCH Publishers, New York S., geb., DM – ISBN 3 Author: David B. Clayson. Computerized Data Management as a Tool to Study Combination Effects in Carcinogenesis. Pages Woo, Yin-tak (et al.).

Chemical Induction of Cancer: Modulation and Combination Effects an Inventory of the Many Factors Which Influence Carcinogenesis by Joseph C. Arcos and Mary F. Argus and Yin-Tak Woo Overview - In the approach to the analysis of disease, including, of course, cancer, two.

Mechanisms of Chemical Carcinogenesis provides information pertinent to the fundamental mechanisms of chemical carcinogenesis. This book surveys the interactions of chemical carcinogens with native DNA, the activation of normal cellular sequences, and the transforming role of.

Lijinsky W. & Taylor H. Carcinogenesis in Sprague-Dawley rats of N-nitroso-N-alkylcarbamate esters. Cancer Lett. 1, Mantel N. & Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease.

natn. Cancer Inst. 22, Schmfihl D, (). Combination effects in chemical car- cinogenesis. Exposure to these compounds can have varying effects, ranging from instant death to a gradual process of chemical carcinogenesis. There are three stages involved in chemical carcinogenesis.

effects of the Combination effects in chemical carcinogenesis book compounds used. Exposure to these compounds can have varying effects, ranging from instant death to a gradual process of chemical carcinogenesis.

There are three stages involved in chemical carcinogenesis. These are defined as initiation, promotion and progression. Each of these stages is characterised by morphological and.

Purchase Carcinogenesis - 1st Edition. Print Book & E-Book. ISBNGet this from a library. Chemical Induction of Cancer: Modulation and Combination Effects an Inventory of the Many Factors which Influence Carcinogenesis.

[Joseph C Arcos; Mary F Argus; Yin-tak Woo] -- In the approach to the analysis of disease, including, of course, cancer, two major thrusts may be distinguished. These may be referred to, in shorthand, as agents and processes: the causative.

Chapter 2 Combination Effects in Chemical Carcinogenesis, Potential Industrial Carcinogens and Mutagens, /S(08)X, (), (). Crossref H. Mayer, W. Bollag, R. Hänni, R. Rüegg, Retinoids, a new class of compounds with prophylactic and therapeutic activities in oncology and dermatology, Experientia, /BF, 34, 9, (), ().

This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers.

The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation 2/5(2). Djulis is a functional grain containing prebiotic dietary fiber, which has an anti-cancer potential.

This study examined the preventive effect of djulis alone or in combination with Lactobacillus acidophilus on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) and dextran sulfate sodium (DSS). Rats were divided into five groups and fed B (AING, blank), C (AING, control), D (10%.

The author reviews the ability of vitamins C and E to inhibit NNC formation in chemical systems, in nitrite‐preserved meat, in experimental animals and in humans. Dietary vitamins C and E both produced 30% to 60% inhibitions in most carcinogenesis experiments employing preformed carcinogens.

Chemical Carcinogenesis: A Brief History of Its Concepts with a Focus on Polycyclic Aromatic Hydrocarbons Stephen Nesnow Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory (NHEERL), Office of Research and Development (ORD), United States Environmental Protection Agency, Research Triangle Park.

Wattenberg (), () has reviewed the literature on the protective effect that several antioxidants (e.g., butylated hydroxytoluene) had on chemical carcinogen-induced carcinogenesis.

Harman () has also shown that antioxidants reduced radiation-induced carcinogenesis and life-span shortening. V itale-Cross L, et al. Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer.

Cancer Prev Res (Phila). ;2(5)– This monograph provides a contemporary account of advances in chemical carcinogenesis. It promotes the view that it is alteration of the DNA by endogenous and exogenous carcinogens that ultimately leads to sporadic mutations which are a root cause of many human cancers.

Chemical Carcinogenesis by Polycyclic Aromatic Hydrocarbons. Franz Oesch. Pages N-Substituted Aromatic Compounds. Genotoxic Effects of Drugs: Experimental Findings Concerning Some Chemical Families of Therapeutic Relevance The course had this as its major objective and the re­ sulting book does reflect it.

Carcinogens, like chemicals with other toxic hazards, often produce adverse effects only in specific organs or tissues. The factors determining whether a chemical induces cancer in an organ range from simple toxicokinetics to complex phenomena such as expression or lack of expression of specific genes.; This volume examines the site-specific factor.

An illustration of an open book. Books. An illustration of two cells of a film strip. Video. An illustration of an audio speaker. Audio. An illustration of a " floppy disk.

Software. An illustration of two photographs. Full text of "Carcinogenesis abstracts". As background to the studies of chemical and radiation carcinogenesis, the book surveys knowledge of cell transformation and carcinogen metabolism. Among the topics reviewed are the transforming genes involved in human malignancy, the genetics and epigenetics of neoplasia, and the single-hit and multi-hit concepts of hepatocarcinogenesis.

Most carcinogens, singly or in combination, produce cancer by interacting with DNA in cells and thereby interfering with normal cellular function. Because of the magnitude of the problem and the ob­ vious need for a much more critical scientific analysis of the process by which cancer is induced (carcinogenesis), it was highly desirable to expose a greater number of scientists with varying background to some of the latest thinking in chemical.

In the earlyypp yg s, Boveri proposed a mutation theory of carcinogenesis but at that time it was not amenable to chemical investigation. Reference: A. Luch. Nature and nurture - lessons from chemical carcinogenesis. Nature Reviews Cancer 5;Does any exposure to a known carcinogen always result in cancer.

Any substance that causes cancer is known as a carcinogen. But simply because a substance has been designated as a carcinogen does not mean that the substance will necessarily cause cancer.

A carcinogen is defined as any substance or radiation that promotes cancer formation or carcinogenesis. Chemical carcinogens may be natural or synthetic, toxic or non-toxic.

Many carcinogens are organic in nature, such as benzo[a]pyrene and viruses. An example of carcinogenic radiation is ultraviolet light. I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since when I entered graduate school in biochemistry at the University of Wisconsin­ Madison.

I immediately started to work with the carcinogenic aminoazo dyes un­ der the direction of Professor CARL BAUMANN. The carcinogenesis of urethane (ethyl carbamate), a byproduct of fermentation that is consistently found in various food products, was investigated with a combination of kinetic experiments and quantum chemical calculations.

The main objective of the study was to find ΔG⧧, the activation free energy for the rate-limiting step of the SN2 reaction among the ultimate carcinogen of urethane. Bingham E, Niemeier RW, Reid JB. Multiple factors in carcinogenesis. Ann N Y Acad Sci. ; – Kotin P. Carcinogenesis. Dose-response relationship and threshold concepts.

Ann N Y Acad Sci. ; – Falk HL. Possible mechanisms of combination effects in chemical carcinogenesis. Oncology. ; 33 (2)–The effects of hyperbaric oxygen (HBO) on mouse skin two-stage chemical carcinogenesis were examined.

Six-week-old inbred CD-1 female mice were divided into the following five groups: group 1, normoxia and application of 25 nmol 7,dimethylbenz[a]anthracene (DMBA) and nmol O-tetradecanoylphorbolacetate (TPA) (n=19); group 2, HBO and DMBA/TPA (n=21); group 3, HBO .The chemical hazards of daily life have led to much hue and cry in Congressional committees and the daily press.

Carcinogenic situations such as atmospheric pollution, cigarette smoking, the effects of weed killers and insecticides have had their share of attention.